Data collected during a multicenter phase-3 clinical trial of a novel drug treatment for hyperkalemia (raised blood potassium) has provided a serendipitous opportunity to examine the variability of plasma potassium measurement. The trial required recruitment of patients with plasma potassium in the hyperkalemic range...

Blood glucose concentration is normally maintained within the approximate reference range of 3.5-8.5 mmol/L (63-153 mg/dL) largely by the synergistic opposing action of two pancreatic hormones: insulin and glucagon. Insulin secretion, induced by rising blood glucose concentration, causes it to fall; whilst glucagon...

Arterial blood gases and other “acute care” biochemical blood tests are frequently ordered during recovery from cardiac arrest. Cardiac arrest, sudden loss of blood flow consequent on cessation of heart activity, is the ultimate medical emergency, frequently exploited for the dramatic nature of its presentation...

Decreased resources coupled with increased demand represents a major problem for healthcare providers that is most publicly manifest in overstretched hospital emergency room (ER) departments around the world. Prolonged waiting times and extended periods of overcrowding in ER, which are increasingly the norm, result in ...

The gold standard sample for blood gas analysis is arterial blood, whereas venous blood is the standard sample for all other biochemical and hematological tests. By comparison with venipuncture, the procedure used to sample venous blood, collection of an arterial blood sample is technically more difficult, as well as...

A simple change in phlebotomy practice – switching from conventional to low-volume sample blood tubes – results in a 42 % reduction in patient blood loss, and consequent reduced risk of iatrogenic anemia. That is the positive headline finding of this recently published study conducted at the Royal Adelaide Hospital in ...

Thanks to KDIGO collaborative guidelines, diagnosis of acute kidney injury (AKI), defined as sudden decrease in kidney function (i.e. sudden decrease in glomerular filtration rate GFR), is simple and straight forwardly based on measurement of serum creatinine concentration and urine output. AKI is confirmed if any of...

Hemoglobin is the oxygen-carrying protein contained in red blood cells that ensures delivery of inspired oxygen from lungs to all tissue cells. This process depends on oxygen forming a reversible ionic link with ferrous iron (Fe⁺⁺) contained within the hemoglobin molecule. Methemoglobin (MetHb) is a dysfunctional form ...

Bilirubin is a product of the hemoglobin catabolism that occurs principally in the spleen where red cells (that contain hemoglobin) are sequestered at the end of their approximate 120-day life. Bilirubin is transported in blood from the spleen to the liver where it is eliminated from the body in bile. Serum bilirubin...

In health total plasma calcium concentration is maintained within the approximate reference range of 8.8-10.5 mg/dL (2.20-2.62 mmol/L) so that raised plasma calcium (hypercalcemia) is usually diagnosed if plasma calcium is >10.5 mg/dL (>2.62 mmol/L) and severe, potentially life-threatening hypercalcemia is roughly...