When it comes to acid base, there is no getting around the name of Ole Siggaard-Andersen (OSA). acutecaretesting.org talks to the world-renowned Danish professor, who has become a legend in the field of blood gas.

Measurement of glucose and lactate after 30 minutes of storage at room temperature can give deviating results of up to 5 % [1,2] and 29 % of the reference value [3] respectively [1,4], due to in vitro glycolysis Glucose and lactate are both important parameters in the surveillance of patients in critical care...

Preanalytical errors are said to be the reason for up to 75 % [1] of all errors in laboratory medicine. The diagnostic consequences depend on the magnitude of the preanalytical error.  In worst case, these errors may lead to mistreatment of patients; in all cases, these errors are an extra workload for the hospital...

England's Oxford Radcliffe Hospitals have a POCT system they consider a success. This is a roadmap of the steps they have taken.

In 1948, Singer and Hastings introduced the concept of buffer base (BB). The change in BB from "normal" was called deltaBB (ΔBB). This change in BB was an expression of the non-respiratory (metabolic) component of an acid-base disturbance. This was the first approximation to base excess. In the 1950s, Astrup and...

p50 is a shorthand representation of hemoglobin-oxygen affinity. A lower p50 is protective in ambient hypoxemia, whereas increasing the p50 should be beneficial in hypoxia due to lung disease, anemia, and tissue ischemia. Despite encouraging theoretical and experimental data, it is not yet established that...

When performing method comparisons, it is important to address a number of preparatory and preanalytical issues to ensure that comparisons solely reflect the analytical differences between the two methods in question. This article provides preparatory and preanalytical checklists that can be used when comparing two...

Preparing for an accreditation inspection is often synonymous with carts full of paper. For some labs, though, the paper hassle associated with accreditation is now history. These labs are letting their data management systems do all the work.

John Severinghaus, who recently turned 80, is one of the pioneers in the field of blood gas. To celebrate his birthday, bloodgas.org has asked him to look back on the first developments leading to the modern blood gas analyzers. The following article has also been published in Anesthesiology, The Journal of the...

Children are not just small adults, and present unique challenges to the clinical laboratory. Blood specimens must be very small; for example, total blood volumes in a premature infant can be as small as 115 mL. Genetic diseases frequently must be detected in the newborn period. Reference values change with age....