Measurement of plasma/serum sodium concentration is one of the most frequently requested blood tests in clinical practice. Although usually performed in the laboratory, the test is also available at the point of care using technology incorporated into blood gas and other point-of-care analyzers. In health, sodium...

Hypoxia and hypoxemia describe states of oxygen deficiency: hypoxia is deficiency in oxygenation at tissue or cellular level whilst hypoxemia is a suboptimal normal partial pressure of oxygen. Hypoxia and hypoxemia are interrelated, as untreated hypoxemia will ultimately result in hypoxia.  It should also be noted...

Ever since the landmark document “To err is human” [1] was released, patient safety has been the paramount objective in US hospitals. “Patient safety” became the catch phrase and focus for all activities; a trend that was rapidly taken up by the rest of the world’s hospitals. Suddenly a new catch phrase – “lean” – ...

The principal function of the protein hemoglobin contained in red blood cells is transport of oxygen in inspired air from lungs to tissue cells. Although normally present in only trace amounts, there are three species of hemoglobin that cannot transport oxygen. The three species, collectively called the dyshemoglobins ...

What does it take to create and maintain a quality point-of-care program in a world-renowned healthcare institution? acutecaretesting.org recently asked that question to Paula Santrach, MD, Interim Chair of the Dept. of Laboratory Medicine and Pathology at the Mayo Clinic in the US. She came back with a list* of 10...

Hospital do Coração (HCor) in São Paolo, Brazil is a hospital for cardiac patients, many of whom are children and newborns. Cardiac patients are closely monitored with respect to acid base and blood gases, and even the newborns have several arterial and venous blood samples drawn daily. Dr Alberto Duarte from the...

Reprinted with permission from British Journal of Nursing, 2004, Vol 13, No 9.  Arterial puncture is the most common method used to obtain a sample for the measurement of arterial blood gases (ABGs) and is essential to guide the prescription of long-term oxygen therapy (LTOT) in patients with chronic hypoxic lung...

The National Academy of Clinical Biochemistry has developed a Laboratory Medicine Practice Guideline for point-of-care testing (POCT). This POCT guideline systematically reviews the scientific literature linking POCT to patient outcome and makes recommendations for the optimal use of POCT in patient care.  This...

The National Kidney Disease Education Program (NKDEP) Laboratory Working Group reviewed problems related to serum creatinine measurement for estimating glomerular filtration rate (GFR) and prepared recommendations to standardize and improve creatinine measurement. The NKDEP recommends using the estimating equation...

Clinical initiatives to maintain blood glucose (BG) within a more normal range have emerged over the last decade as a growing trend in clinical management of patients in acute care settings. This trend has grown due to the increased focus of research in glycemic control (GC) and results indicating that GC is...