Iatrogenic phlebotomy loss resulting from the intensive clinical monitoring in the weeks immediately following birth remains the primary cause of neonatal anemia and the need for red-blood-cell (RBC) transfusion. Reducing RBC transfusion needs in the neonatal intensive care unit (NICU) requires new approaches for...

Capillary blood sampling via a heel lance is the most common procedure performed in hospitalized neonates. Adequate training and supervision of the personnel performing the procedure is necessary to prevent/minimize inadequate sampling volumes, false laboratory results and complications such as pain. Efforts should be ...

Methods for the measurement of hemoglobin (Hb) were first developed well over a century ago, so that hemoglobin was among the first diagnostic blood tests available to clinicians during the first decades of the 20th century when laboratory medicine was in its infancy.  Today it is the most frequently requested blood...

The collection of arterial specimens with glass syringes and immediate storage in iced water was the accepted industry standard for many years. Practice has changed over the past several years to blood gas sample collection in plastic syringes, likely due to the cost, safety and convenience of plastic. This change ...

Lately, everybody seems to be talking about reducing testing errors and improving patient safety. But where do you begin? The answer may be to look beyond the error itself and instead focus on what is causing it. Michael Astion, Associate Professor, Director of the University of Washington’s Reference Laboratory...

Preanalytical errors are a significant source of medical errors that can jeopardize patient safety. Proper specimen labeling practices are critical components of effective and accurate patient identification.  These variables are now considered part of the preexamination process in the newest CLSI quality system...

Supported by Pennsylvania Hospital Kernicterus Fund and the Eglin Fund In the late 1980s, the question whether bilirubin damaged the brain of healthy infants was unanswered. The absence of documented evidence influenced the formulation of the 1994 consensus-based guidelines...

Point-of-care testing (POCT) results, like other forms of laboratory data, hold potential hidden information that can be utilized to improve patient care.  The technique of extracting useful information from vast amounts of data is termed “data mining”. Technological solutions are now available to meet the challenges ...

Simple data-mining algorithms can be applied to point-of-care testing (POCT) data to document compliance of quality control, operator training and to identify potential preanalytical errors. Data can be manipulated to automate manual review and other laborious processes for identifying data trends, verifying...

Oxygen is one of the most widely used drugs in medicine, and especially so in the newborn period. In many cases, oxygen supplementation is needed and is life-giving, but we are also aware of its toxic effects. In spite of this, we still do not know exactly what is the correct way to administer this drug. It is a...