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Introduction This article features a general background of the analytical characteristics associated with cardiac troponin testing. It addresses the following areas: Introduction to troponin What is the 99^th percentile upper reference limit (URL) and why do we use it? Determination of the 99^th percentile...

Introduction Since the first publications on cardiac troponin (cTn) in the 1970s, around 20.000 scientific reports on this powerful biomarker of myocardial injury have been published. Over time, cTn assays improved their analytical performance and became the designated biomarker for ruling out or ruling in acute...

Because measurements of GFR are tedious, estimated GFRs based on creatinine or cystatin C are widely used for assessing kidney function. Both measured GFRs and the Staging System for CKD based on GFR have analytical and clinical shortcomings. The advantages of serum creatinine and cystatin C, and eGFR will be...

This article explores the potential benefits of point-of-care testing in the ED. Price and St. John provide a detailed description on how to approach four common aspects of point-of-care testing (POCT) in the ED, specifically, the challenges of adopting POCT, the impact of POCT on clinical decisions, the impact of...

Reprinted with permission from Biochemia Medica. The journal of Croatian Society of Medical Biochemistry and Laboratory Medicine. Biochemia Medica 2016;26(3):318-36  Blood gas analysis (BGA) is exposed to risks of errors caused by improper sampling, transport and storage conditions. The Clinical and Laboratory...

Bacterial infections are one of the major reasons for patients presenting to the ED - and the main cause of death in elderly patients. It is important to identify elderly patients with bacterial infections early and initiate treatment in the ED for a better outcome. However, an infection in an elderly patient can be...

When a new D-dimer method is evaluated, it’s typically compared to an established D-dimer method using both an analytical and a clinical comparison. Analytical comparisons should be discouraged, as they do not give any useful information about the potential clinical usability of the assay. D-dimer assay comparisons...

Point-of-care testing (POCT) covers a broad range of pathology and non-pathology testing. The volume of POCT is rapidly increasing with an annual growth rate of 12-15 %. By virtue of its compactness, portability, and the feasibility of operation by non-laboratory personnel, where fast and accurate testing methods and...

With the ultimate goal of improving patient care, adoption of point-of-care testing (POCT) continues to grow at a high rate. The ability to deliver fast and reliable results near the patient is a key driver for improving patient outcomes and optimizing clinical workflow. While there are many advantages, controlling...