In the past years, emergency rooms (ER) all over Germany, especially those of maximum-care hospitals, have been faced with an increasing number of patients. This is caused by a variety of factors, including demographic changes, inflexible ambulant services and an overreaching demand for healthcare services. ER...

CO-oximetry provides the means for automated spectrophotometric measurement of the concentration of total hemoglobin (ctHb) in blood and the percentages of the four hemoglobin derivatives that total hemoglobin comprises: oxyhemoglobin (O₂Hb); deoxyhemoglobin (HHb); carboxyhemoglobin (COHb); and methemoglobin (MetHb)....

Point-of-care testing (POCT) for key laboratory variables may help clinicians assess the level of acuteness and the level of care necessary in the management of deteriorating ward patients. We used a multibiomarker POCT panel including B-type natriuretic peptide (BNP), D-dimer, myoglobin (Myo), creatine kinase MB...

Neonates nearly always experience their single largest day of blood loss on the day of birth due to admission laboratory testing. The term "admission laboratory testing" refers to the initial blood tests done when a baby is born and admitted to the NICU.  Total circulating blood volume in a 3.5 kg term newborn is 280...

Ensuring adequate oxygen delivery to tissues is a prime objective of acute/critical medical care. There is no routinely available method for directly monitoring tissue oxygenation; instead clinicians must depend on available indirect measures. Although not the only factor to be considered, measurement of the amount of ...

The use of natriuretic peptides like B-type natriuretic peptide (BNP) and N-terminal proBNP (NT-proBNP) has increased during the last decade and so has the medical evidence of their utility. This article highlights natriuretic peptide synthesis and release. Based on essential clinical trials the article gives medical...

Reprinted from Ann Lab Med 2013 Sep; 33(5):309-18. Christenson E, Christenson RH: "The role of cardiac biomarkers in the diagnosis and management of patients presenting with suspected acute coronary syndrome". Myocardial infarction (MI) is the leading cause of death in the developed world. Biomarkers have an...

In high-level athletes preparation, using point-of-care testing (POCT) in sports-specific environments, we tried to define and control the levels of exercise intensities (“energy training zones”), to quantify metabolic functionality (sports-specific energy sources, baseline conditions, functional costs of exercise in...

Fast, accurate blood gas testing is a critical component to managing the post isolated coronary artery bypass (ISO-CAB) patient in the hospital intensive care unit/coronary care Unit (ICU/CCU). Post ISO-CAB patients are admitted to the ICU/CCU after surgery mechanically ventilated. Evidence-based medicine supports...

With increasing age, an unspecific rise of fibrin degradation product in blood is observed. Thus, the D-dimer test to rule out thromboembolic events has a high false positive rate in elderly patients. In 2010, Douma et al introduced a formula to adjust D-dimer cut-off values for age in outpatients >50 years: Age ×...