Although creatinine clearance has been the mainstay for estimating glomerular filtration rate (GFR) in laboratories for the past half-century, prediction equations based on serum creatinine and other routine serum analytes are now available which enable reporting of a calculated GFR using the Modification of Diet in...

As point-of-care testing (POCT) continues to expand in the hospital environment, the desire of physicians to participate in the performance of testing may increase. This article discusses the required competencies for a physician who wishes to be involved in laboratory testing and some practical considerations for...

The National Academy of Clinical Biochemistry has developed a Laboratory Medicine Practice Guideline for point-of-care testing (POCT). This POCT guideline systematically reviews the scientific literature linking POCT to patient outcome and makes recommendations for the optimal use of POCT in patient care.  This...

The National Kidney Disease Education Program (NKDEP) Laboratory Working Group reviewed problems related to serum creatinine measurement for estimating glomerular filtration rate (GFR) and prepared recommendations to standardize and improve creatinine measurement. The NKDEP recommends using the estimating equation...

This is the second in a series of articles. The first essay, “Quality control in theory and practice – a gap analysis”, published here in January 2006 raised the question: Has “the system” given front-line laboratory workers the knowledge and tools they need to make quality control decisions wisely – or is there a...

This is the second of two articles about the risks and benefits of red-cell transfusion directed at healthcare professionals without any particular transfusion expertise. The focus of the first article was the risks and the extensive measures taken to minimize those risks. For this second article, attention turns to...

Millions of times every day, in a myriad of distinctive laboratories around this globe, front-line workers make the final decision on the quality of results they report. If they decide the quality is “OK”, patient results are released to impact clinical decisions, and proficiency values reflect the overall ability...

Although often of life-saving benefit, transfusion of donated red cells is associated with considerable potential risk for the recipient patient. This article, directed at healthcare professionals without any particular transfusion expertise, outlines these risks and the measures taken to minimize them. Particular...

Laboratorians need to take ownership of errors, identifying, analyzing and reducing them, thereby increasing patient safety. A Client Services Department, customer care representatives, a service improvement coordinator, “morning report”, electronic error tracking and reporting mechanisms, point-of-care support...

The collection of arterial specimens with glass syringes and immediate storage in iced water was the accepted industry standard for many years. Practice has changed over the past several years to blood gas sample collection in plastic syringes, likely due to the cost, safety and convenience of plastic. This change ...