With the increasing number of blood tests performed at the point of care (POC), it has become more and more important to perform method comparison studies, comparing new methods to the existing methods used in the laboratory (LAB). This is done primarily to ensure that uniform results are reported throughout the...

It is more and more common that computer-based systems in hospitals are serviced or "looked after" by service engineers dialing in from remote locations.  The combination of highly computerized laboratory equipment and the emerging network technologies makes remote support a very attractive possibility. In many...

p50 is a shorthand representation of hemoglobin-oxygen affinity. A lower p50 is protective in ambient hypoxemia, whereas increasing the p50 should be beneficial in hypoxia due to lung disease, anemia, and tissue ischemia. Despite encouraging theoretical and experimental data, it is not yet established that...

When performing method comparisons, it is important to address a number of preparatory and preanalytical issues to ensure that comparisons solely reflect the analytical differences between the two methods in question. This article provides preparatory and preanalytical checklists that can be used when comparing two...

If you think only private corporations can call themselves project organizations, think again. Hospitals around the world are increasingly seeing themselves as project organizations and relying on project groups to explore and implement new technologies.  Meanwhile, healthcare workers participating in these projects...

In a 1999 study, the US Institute of Medicine (IOM) concluded that 44,000 to 98,000 hospitalized Americans die each year from preventable medical errors. While the number of serious medical errors attributable to point of care (point-of-care testing, POCT) is not known, the testing environment (patient bedside) and...

The measurement of the electrolytes in blood is one of the most frequently performed measurements as the electrolytes are of major physiological importance for numerous functions of the body. Analysis of electrolytes such as sodium and potassium are performed in the traditional clinical chemistry laboratory, but are...

"Six Sigma" is the latest trend in quality management and is being widely implemented in business and industry today. Six Sigma represents an evolution of Total Quality Management (TQM), providing a more quantitative framework for evaluating process performance and clearer goals for process improvement. The...

In the U.S. all testing, including decentralized testing, is regulated according to the Clinical Laboratory Improvement Amendments of 1988 (CLIA'88). Congress passed CLIA'88 to ensure accurate, reliable, and timely test results regardless of test site. These quality control, quality assurance, and proficiency tesing...

Children are not just small adults, and present unique challenges to the clinical laboratory. Blood specimens must be very small; for example, total blood volumes in a premature infant can be as small as 115 mL. Genetic diseases frequently must be detected in the newborn period. Reference values change with age....