Hypoxia and hypoxemia describe states of oxygen deficiency: hypoxia is deficiency in oxygenation at tissue or cellular level whilst hypoxemia is a suboptimal normal partial pressure of oxygen. Hypoxia and hypoxemia are interrelated, as untreated hypoxemia will ultimately result in hypoxia.  It should also be noted...

What does it take to create and maintain a quality point-of-care program in a world-renowned healthcare institution? acutecaretesting.org recently asked that question to Paula Santrach, MD, Interim Chair of the Dept. of Laboratory Medicine and Pathology at the Mayo Clinic in the US. She came back with a list* of 10...

Hospital do Coração (HCor) in São Paolo, Brazil is a hospital for cardiac patients, many of whom are children and newborns. Cardiac patients are closely monitored with respect to acid base and blood gases, and even the newborns have several arterial and venous blood samples drawn daily. Dr Alberto Duarte from the...

Reprinted with permission from British Journal of Nursing, 2004, Vol 13, No 9.  Arterial puncture is the most common method used to obtain a sample for the measurement of arterial blood gases (ABGs) and is essential to guide the prescription of long-term oxygen therapy (LTOT) in patients with chronic hypoxic lung...

In Geneva in 1821, a French nobleman Jacques Alexandre Le Jumeau, Vicomte de Kergaradec, became the pioneer of modern fetal monitoring. He described the sound of the fetal heartbeat, as he used the newly invented stethoscope (by Laennec, France 1819) and applied it to the abdominal wall of a pregnant woman [1]. The...

Although creatinine clearance has been the mainstay for estimating glomerular filtration rate (GFR) in laboratories for the past half-century, prediction equations based on serum creatinine and other routine serum analytes are now available which enable reporting of a calculated GFR using the Modification of Diet in...

As point-of-care testing (POCT) continues to expand in the hospital environment, the desire of physicians to participate in the performance of testing may increase. This article discusses the required competencies for a physician who wishes to be involved in laboratory testing and some practical considerations for...

The National Academy of Clinical Biochemistry has developed a Laboratory Medicine Practice Guideline for point-of-care testing (POCT). This POCT guideline systematically reviews the scientific literature linking POCT to patient outcome and makes recommendations for the optimal use of POCT in patient care.  This...

The National Kidney Disease Education Program (NKDEP) Laboratory Working Group reviewed problems related to serum creatinine measurement for estimating glomerular filtration rate (GFR) and prepared recommendations to standardize and improve creatinine measurement. The NKDEP recommends using the estimating equation...

Clinical initiatives to maintain blood glucose (BG) within a more normal range have emerged over the last decade as a growing trend in clinical management of patients in acute care settings. This trend has grown due to the increased focus of research in glycemic control (GC) and results indicating that GC is...