The management at the emergency department of patients presenting with symptoms of chest pain and/or acute dyspnea accounts for a substantial proportion of emergency care resources. In the work-up of these patients the blood measurements of cardiac troponins and brain natriuretic peptides are recommended by current...

With increasing age, an unspecific rise of fibrin degradation product in blood is observed. Thus, the D-dimer test to rule out thromboembolic events has a high false positive rate in elderly patients. In 2010, Douma et al introduced a formula to adjust D-dimer cut-off values for age in outpatients >50 years: Age ×...

In a regional top-management decision, our laboratory was given the mission to control and quality assure all POCT activities in a regional network of 10 hospitals with emergency units. Based on previous work, new region-wide recommendations, procurements,  IT connectivity, services, training, accreditation (ISO...

The appropriate number of significant figures is important in order to have a meaningful level of resolving power when reporting analytical concentrations. Various methods or criteria can be used when estimating how many significant figures are needed. In most cases three significant figures (two true plus one...

Troponin values above the 99th percentile and increasing/falling values found by serial testing in addition to signs and symptoms of myocardial ischemia means AMI. Low troponin values, near or below the 99th percentile, can be used for prognosis. Highest hazard ratios were found when using the 90th percentile,...

Five years of data on percutaneous injuries (PIs) from the EPINet multi-hospital sharps injury database at the University of Virginia were analyzed to understand exposure risks faced by personnel in intensive care/critical care settings. Of 687 PIs in intensive care units (ICUs), nurses had the highest proportion of...

Numerous method comparison studies of blood gas analyzer methods have been published in the literature; unfortunately, several studies show flaws in one or several aspects of experimental design, execution, statistical analysis or interpretation of results. The most common flaw seems to be an inability to separate...

The understanding and management of ventilation-perfusion (V/Q) relationships represents a cornerstone of intensive care unit (ICU) patient management.  The physiologic shunt calculation can reliably reflect the degree of gas exchange attributable to intrapulmonary disease or intracardiac shunting regardless of other ...

Whether performed by one "traditional" or several "point-of-care" devices, all Multi-Profile Blood Gas (MPBG) results must be accurate and precise if they are to be effective in managing critically ill patients. Optimal analytical quality control of multi-profile blood gas analysis requires a good quality assurance...