Hemoglobin is the oxygen-carrying protein contained in red blood cells (erythrocytes). Although normally present in only trace amounts, there are three species of hemoglobin that cannot transport oxygen.  The three species, collectively called dyshemoglobins because of their functional redundancy, are methemoglobin,...

Methods for the measurement of hemoglobin (Hb) were first developed well over a century ago, so that hemoglobin was among the first diagnostic blood tests available to clinicians during the first decades of the 20th century when laboratory medicine was in its infancy.  Today it is the most frequently requested blood...

Five years of data on percutaneous injuries (PIs) from the EPINet multi-hospital sharps injury database at the University of Virginia were analyzed to understand exposure risks faced by personnel in intensive care/critical care settings. Of 687 PIs in intensive care units (ICUs), nurses had the highest proportion of...

In 1998, Fleury Diagnostics, Brazil's most comprehensive center for diagnostic medicine and pathology with 1,600 employees and 2,500 patients a day, implemented its own system for managing documents necessary for certification and point-of-care testing (POCT) programs. The system was entirely developed in-house in the ...

In 2001, Belgian professor Greet Van den Berghe, PhD, and her colleagues at the Leuven University Hospital began a small revolution with the publication of the 2001 study “Intensive insulin therapy in critically ill patients”. According to the study, tighter glucose control based on insulin therapy lowered rates of...

Oxygen is one of the most widely used drugs in medicine, and especially so in the newborn period. In many cases, oxygen supplementation is needed and is life-giving, but we are also aware of its toxic effects. In spite of this, we still do not know exactly what is the correct way to administer this drug. It is a...

Is it a good idea to rely on vendors to help develop training materials for point-of-care testing staff? According to the lab group responsible for point-of-care (POC) testing at the Malmö University Hospital in Sweden, vendor cooperation can help you achieve a better result, faster. However, the better prepared you ...

The significance of good practice during the pretesting phase of clinical laboratory investigation cannot be overemphasized. The production of high-quality, accurate results, which are clinically useful, depends as much on practice before the patient’s sample reaches the laboratory as it does on the analytical phase...

Neonatology, perhaps more than any other field in medicine, has undergone dramatic improvements in care over the last several decades. One of the main areas of advancement is the ability to mechanically ventilate premature infants with a variety of neonatal lung conditions. As survival of premature infants has...

Test results are commonly interpreted against population-based reference (normal) intervals, which should be provided on every laboratory report, irrespective of whether the test has been done as point-of-care testing or in a clinical laboratory. Reference intervals are difficult to generate properly if international ...