The integrity and function of all cells depend on an adequate supply of oxygen. Severe acute illness is frequently associated with inadequate tissue perfusion and/or reduced amount of oxygen in blood (hypoxemia) leading to tissue hypoxia.  If not reversed, tissue hypoxia can rapidly progress to multiorgan failure and ...

In 2005, acutecaretesting.org interviewed Dr Michael Astion, an active spokesperson for patient safety and reduction of lab errors, on the main issues surrounding the topic. Since then, a lot has changed… or has it? In a follow-up interview with Astion, acutecaretesting.org gauges the status of patient safety year...

This essay is a follow-up to the 2006 series expressing concern that there is a widespread gap between QC theory and QC practice. Now we are giving you, the reader, the opportunity to rate your own QC practice and to help prove or disprove that gap.  If the QC theories generally recommended by recognized QC experts ...

Homeostatic mechanisms ensure that in health the extracellular fluid (ECF) concentration of electrolytes, including calcium, is maintained within well-defined limits. Abnormality in ECF calcium concentration can have profound adverse effects.  The most common means of assessing calcium status is to measure total...

Technology is available worldwide to help us carry out diversified tasks and work in an easier, faster, and more efficient way.  Furthermore, technology can help us prevent analyzer downtime and failures that may have serious consequences for both business and patients. This article gives an overview of some of the...

Blood gas analysis is a complex field that has a direct impact on patient care in a critical care environment. Healthcare professionals consistently emphasize high-quality results in order to properly treat patients, and recognize the need and usefulness of quality standards.  Using a path-of-workflow analysis as part ...

The significance of good practice during the pretesting phase of clinical laboratory investigation cannot be  overemphasized. The production of high-quality, accurate results which are clinically useful depends as much on practice before the patient’s sample reaches the laboratory as it does on the analytical phase...

Measurement of plasma/serum sodium concentration is one of the most frequently requested blood tests in clinical practice. Although usually performed in the laboratory, the test is also available at the point of care using technology incorporated into blood gas and other point-of-care analyzers. In health, sodium...

Hypoxia and hypoxemia describe states of oxygen deficiency: hypoxia is deficiency in oxygenation at tissue or cellular level whilst hypoxemia is a suboptimal normal partial pressure of oxygen. Hypoxia and hypoxemia are interrelated, as untreated hypoxemia will ultimately result in hypoxia.  It should also be noted...

Ever since the landmark document “To err is human” [1] was released, patient safety has been the paramount objective in US hospitals. “Patient safety” became the catch phrase and focus for all activities; a trend that was rapidly taken up by the rest of the world’s hospitals. Suddenly a new catch phrase – “lean” – ...